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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

Beta>-agonists act as bronchodilators in asthma and chronic obstructive pulmonary disease (COPD). With an effective inhalation technique, the optimum deposition in the lungs from a metered dose...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

Patients and Methods Ten ambulatory patients were included. They were never smokers or nonsmokers, who had not been smoking for the last five years. They all had a clinical history of bronchial asthma...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

Ethics The patients were given verbal and written information, and consent to participate was obtained from all. The study was approved by the Ethics Committee of Aarhus and was in accordance with the...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

The patients were instructed to shake the aerosol and actuate twice into the spacer. Afterwards the Nebuhaler-PEP-mask was placed tightly over mouth and nose and the patients inhaled slowly from FRC...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

Diary and Clinical Control The patients filled in a diary card. Questions regarding dyspnea, cough, and amount of sputum during the day were graded from 0 to 3 (none, mild, moderate, and severe) and...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

The symptom scores, the additional use of inhaled terbutaline, FEV|, and FVC were analyzed by Friedman test and Wilcoxon rank sum test for paired data. Nonparametric analysis was used because of the...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

Lung Function Measurements at the Clinic The FEVi and FVC after all treatments were significantly higher than the values measured at the start of the study (Table 3), but there was no significant...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

The increases in PEF were modest and apparently not of long duration, since there were no differences between the treatments concerning baseline lung function. This was probably due to the severity of...

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

We find it interesting that PEP alone showed a uniform pattern of significant increases in PEF, though to a minor extent than after terbutaline treatment, indicating that PEP alone dilates airways....

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Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined...

The effect on airway secretion was supported by a previous study showing a marked decrease in the number of acute exacerbations in chronic bronchitis with daily use of chest physiotherapy with PEP-mask...

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